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Article

Parkin Gene Therapy for α-Synucleinopathy: A Rat Model of Parkinson's Disease

1 Feb 2005

Abstract excerpt

Parkin is known to mitigate alpha-synuclein-induced neuronal cell death in vitro, which suggests that the parkin gene therapy is a candidate for therapeutic strategies for Parkinson's disease (PD). In the present study, the parkin gene therapy was investigated for its ameliorative effects on alpha-synucleinopathy in substantia nigra (SN) of rats. A recombinant adeno-associated viral (rAAV) vector system has...

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PMID: 15761265
DOI: 10.1089/hum.2005.16.262

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