Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

Abstract excerpt

BACKGROUND: α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activity and cause autosomal recessive early onset parkinsonism. RESULTS: We tested how these two genes interact by examining the effects of parkin on...

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