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Article

Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.

The Journal of biological chemistry - 14 Nov 2003

Martin Negin P, Lefkowitz Robert J, Shenoy Sudha K

Abstract excerpt

The seven-transmembrane-spanning vasopressin V2 receptor (V2R) is a Gs-coupled receptor that is rapidly phosphorylated and internalized following stimulation with the agonist, arginine-vasopressin. Herein, we show that the V2R is ubiquitinated following agonist stimulation. V2R-ubiquitination is not observed in a beta-arrestin1,2 deleted mouse fibroblast cell line and is restored following introduction of...

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Identifiers

PMID: 12960162
DOI: 10.1074/jbc.M308285200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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