Article
Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors.
Molecular pharmacology - 1 Mar 2008
Schwieger Isabel, Lautz Katja, Krause Eberhard, Rosenthal Walter, Wiesner Burkhard, Hermosilla Ricardo
Abstract excerpt
The endoplasmic reticulum-associated degradation (ERAD), the main quality control pathway of the cell, is crucial for the elimination of unfolded or misfolded proteins. Several diseases are associated with the retention of misfolded proteins in the early secretory pathway. Among them is X-linked nephrogenic diabetes insipidus, caused by mutations in the gene encoding the V2 vasopressin receptor (V2R). We studied...
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