Article
The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias.
Oncotarget - 30 Dec 2014
Athanasakis Emmanouil, Melloni Elisabetta, Rigolin Gian Matteo, Agnoletto Chiara, Voltan Rebecca, Vozzi Diego, Piscianz Elisa, Segat Ludovica, Dal Monego Simeone, Cuneo Antonio, Secchiero Paola, Zauli Giorgio
Abstract excerpt
By using next generation sequencing, we have analyzed 108 B chronic lymphocytic leukemia (B-CLL) patients. Among genes involved in the TP53 pathway, we found frequent mutations in ATM (n=18), TP53 (n=10) and NOTCH1 (n=10) genes, rare mutations of NOTCH2 (n=2) and CDKN1A/p21 (n=1) and no mutations in BAX, MDM2, TNFRSF10A and TNFRSF10B genes. The in vitro treatment of primary B-CLL cells with the activator of p53...
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