Article
Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoter.
Gene - 14 Aug 2003
Xia Jiazeng, Zhou Zhen Hong, Bubien James K, Fuller Catherine M, Markert James M, Mapstone Timothy B, Gillespie G Yancey, Benos Dale J
Abstract excerpt
Acid sensing ion channel (ASIC)2 belongs to the amiloride-sensitive Na(+)-channel/ degenerin family. Our previous studies suggested that differential regulation of ASIC2 expression occurs between high-grade glial-derived tumor cells and normal astrocytes. To investigate the mechanisms involved in the regulation of ASIC2 gene expression, the human ASIC2 promoter region (-1551 to +117) was cloned and characterized....
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