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Article

Genetic variants in the promoter region of the calcium-sensing receptor gene are associated with its down-regulation in neuroblastic tumors.

Molecular carcinogenesis - 1 Apr 2017

Masvidal Laia, Iniesta Raquel, García Marta, Casalà Carla, Lavarino Cinzia, Mora Jaume, de Torres Carmen

Abstract excerpt

We have previously reported that the calcium-sensing receptor (CaSR) is expressed in benign, differentiated neuroblastic tumors, and epigenetically silenced in undifferentiated, malignant cases. Furthermore, cinacalcet, an allosteric activator of the CaSR, reduces neuroblastoma tumor growth in preclinical models. However, to identify patients that might benefit from this treatment, a complete understanding of...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Down-Regulation

Share to Gene Expression Regulation, Neoplastic

Share to Neuroblastoma

Share to Promoter Regions, Genetic

Share to Receptors, Calcium-Sensing

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Identifiers

PMID: 27862333
DOI: 10.1002/mc.22589

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CASR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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