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Article

Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function.

American journal of physiology. Cell physiology - 1 Feb 2009

Bashari Edlira, Qadri Yawar J, Zhou Zhen-Hong, Kapoor Niren, Anderson Susan J, Meltzer Robert H, Fuller Catherine M, Benos Dale J

Abstract excerpt

Human acid-sensing ion channel 1b (hASIC1b) is a H(+)-gated amiloride-sensitive cation channel. We have previously shown that glioma cells exhibit an amiloride-sensitive cation conductance. Amiloride and the ASIC1 blocker psalmotoxin-1 decrease the migration and proliferation of glioma cells. PKC also abolishes the amiloride-sensitive conductance of glioma cells and inhibits hASIC1b open probability in planar...

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Source

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Identifiers

PMID: 19091960
DOI: 10.1152/ajpcell.00200.2008
PMCID: PMC2643847

Genes

ASIC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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