Article
A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke.
The Journal of experimental medicine - 20 Mar 2006
Mallolas Judith, Hurtado Olivia, Castellanos Mar, Blanco Miguel, Sobrino Tomás, Serena Joaquín, Vivancos José, Castillo José, Lizasoain Ignacio, Moro María A, Dávalos Antoni
Abstract excerpt
It remains unclear why some individuals are susceptible to excitotoxicity after stroke. A possible explanation is impaired glutamate uptake. We have found a highly prevalent polymorphism in the promoter of the glutamate transporter EAAT2 gene that abolishes a putative regulatory site for activator protein-2 (AP-2) and creates a new consensus binding site for the repressor transcription factor GC-binding factor 2...
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