Article
Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.
The Biochemical journal - 1 Jun 2003
Zhong Can, Chen Chin, Kilberg Michael S
Abstract excerpt
Transcription from the human asparagine synthetase (A.S.) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation. These two independent nutrient-sensing pathways converge on the same set of genomic cis -elements, referred to as nutrient sensing-response elements (NSREs) 1 and 2, within the A.S. promoter. The present report uses...
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