Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).

doi:10.1074/jbc.M112.372441

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Article

Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).

The Journal of biological chemistry - 28 Sept 2012

Cohen Limor, Asraf Hila, Sekler Israel, Hershfinkel Michal

Abstract excerpt

Zinc activates a specific Zn(2+)-sensing receptor, ZnR/GPR39, and thereby triggers cellular signaling leading to epithelial cell proliferation and survival. Epithelial cells that express ZnR, particularly colonocytes, face frequent changes in extracellular pH that are of physiological and pathological implication. Here we show that the ZnR/GPR39-dependent Ca(2+) responses in HT29 colonocytes were maximal at pH...

Topics

Aspartic Acid
Binding Sites
Biological Transport
Calcium
Cell Line, Tumor
Colon
HEK293 Cells
Histidine
Humans
Hydrogen-Ion Concentration
Ions
Mutation
Receptors, G-Protein-Coupled
Signal Transduction
Zinc

Source

Open in PubMed Open full text

Identifiers

PMID: 22879599
DOI: 10.1074/jbc.M112.372441
PMCID: PMC3460437

Genes

GPR39

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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