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Article

Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2008

Sekkali Belaïd, Tran Hong Thi, Crabbe Ellen, De Beule Christophe, Van Roy Frans, Vleminckx Kris

Abstract excerpt

Chromatin structure and gene transcription regulation are intimately linked, and mosaic expression of randomly integrated transgenes into the genome is frequently observed. This variegation of transgene expression is likely due to the genomic integration site, which can affect the behavior of the integrated DNA sequence in a positive or a negative way. Insulators are a class of DNA elements that can protect genes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18359926
DOI: 10.1096/fj.07-098111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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