Article
Imprinting by DNA methylation: from transgenes to endogenous gene sequences.
Development (Cambridge, England). Supplement - 1 Jan 1990
Reik W, Howlett S K, Surani M A
Abstract excerpt
A number of transgenes in the mouse show variation in methylation and expression phenotypes dependent on parental transmission. It appears that there exist at least two types of transgene imprinting; one is retained on an essentially homozygous background, while the other requires heterozygosity...
Topics
- Animals
- Chromosomes
- Crosses, Genetic
- DNA
- Female
- Gene Expression Regulation
- Male
- Methylation
- Mice
- Mice, Transgenic
- Phenotype
- Regulatory Sequences, Nucleic Acid