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Article

Distal transgene insertion affects CpG island maintenance during differentiation.

The Journal of biological chemistry - 25 Apr 2008

Strathdee Douglas, Whitelaw C Bruce A, Clark A John

Abstract excerpt

About half of all genes have a CpG island surrounding the promoter and transcription start site. Most promoter CpG islands are normally unmethylated in all tissues, irrespective of the expression level of the associated gene. Establishment of the appropriate patterns of DNA methylation in the genome is essential for normal development and patterns of gene expression. Aberrant methylation of CpG islands and...

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PMID: 18308728
DOI: 10.1074/jbc.M709805200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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