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Article

Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites.

Molecular biology and evolution - 1 Nov 2003

Wang Hurng-Yi, Tang Hua, Shen C-K James, Wu Chung-I

Abstract excerpt

In an attempt to identify all fast-evolving genes between human and other primates, we found three glycophorins, GPA, GPB, and GPE, to have the highest rate of nonsynonymous substitutions among the 280 genes surveyed. The Ka/Ks ratios are generally greater than 3 for GPA, GPB, and GPE in human, chimpanzee, and gorilla, indicating positive selection. The uniformly high substitution rate across loci can be...

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PMID: 12949139
DOI: 10.1093/molbev/msg185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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