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Article

Human pseudogenes of the ABO family show a complex evolutionary dynamics and loss of function.

Glycobiology - 1 Jun 2009

Casals Ferran, Ferrer-Admetlla Anna, Sikora Martin, Ramírez-Soriano Anna, Marquès-Bonet Tomàs, Despiau Stéphanie, Roubinet Francis, Calafell Francesc, Bertranpetit Jaume, Blancher Antoine

Abstract excerpt

The GT6 glycosyltransferases gene family, that includes the ABO blood group, shows a complex evolution pattern, with multiple events of gain and loss in different mammal species. In humans the ABO gene is considered the sole functional member although the O allele is null and is fixed in certain populations. Here, we analyze the human GT6 pseudogene sequences (Forssman, IGB3, GGTA1, GT6m5, GT6m6, and GT6m7) from...

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Source

Identifiers

PMID: 19218399
DOI: 10.1093/glycob/cwp017

Genes

ABO
GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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