Article
Sequence diversification and exon inactivation in the glycophorin A gene family from chimpanzee to human.
Journal of molecular evolution - 1 Oct 1995
Huang C H, Xie S S, Socha W, Blumenfeld O O
Abstract excerpt
In humans, the allelic diversity of MNSs glycophorins (GP) occurs mainly through the recombinational modulation of silent exons (pseudoexons) in duplicated genes. To address the origin of such a mechanism, structures of GPA, GPB, and GPE were determined in chimpanzee, the only higher primate know...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- DNA
- DNA Primers
- DNA Probes
- DNA, Complementary
- Exons
- Genetic Variation
- Glycophorins
- Hominidae
- Humans
- Molecular Sequence Data
- Multigene Family
- Pan troglodytes
- Polymerase Chain Reaction
- Restriction Mapping