Article
Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus.
Cancer research - 1 Jun 2003
Dirmeier Ulrike, Neuhierl Bernhard, Kilger Ellen, Reisbach Gilbert, Sandberg Mark L, Hammerschmidt Wolfgang
Abstract excerpt
The EBV latent membrane protein 1 (LMP1) is an integral membrane protein that acts like a constitutively activated receptor. LMP1 interacts with members of the tumor necrosis factor receptor-associated factor family, as well as with tumor necrosis factor receptor-associated death domain, resulting in induction of nuclear factor-kappaB, the p38 mitogen-activated protein kinase pathway, and the c-Jun NH(2)-terminal...
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