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LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cells

19 Dec 2023

Abstract excerpt

Introduction: Epstein-Barr virus (EBV) infection in humans is associated with a wide range of diseases including malignancies of different origins, most prominently B cells. Several EBV latent genes are thought to act together in B cell immortalization, but a minimal set of EBV genes sufficient for transformation remains to be identified. Methods: Here, we addressed this question by transducing human peripheral B...

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PMID: 38169736
DOI: 10.3389/fimmu.2023.1331730

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