Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

11 Jul 2011

Abstract excerpt

Epstein-Barr virus nuclear antigen 2 (EBNA2) regulation of transcription through the cell transcription factor RBPJ is essential for resting B-lymphocyte (RBL) conversion to immortal lymphoblast cell lines (LCLs). ChIP-seq of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5,151 and RBPJ at 10,529 sites. EBNA2 sites were enriched for RBPJ (78%), early B-cell factor (EBF, 39%), RUNX (43%), ETS (39%), NFκB (22%),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Immunodeficiency and Autoimmune Disorders
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21746931
DOI: 10.1073/pnas.1108892108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growthPMID 21746931Read ↗

RNA Sequencing Analyses of Gene Expression during Epstein-Barr Virus Infection of Primary B LymphocytesSemantic proximity Read ↗

A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growthSemantic proximity Read ↗

Epstein–Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexesSemantic proximity Read ↗

Epstein–Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infectionSemantic proximity Read ↗

EBV Latency Programs: Molecular and Epigenetic Regulation and Its Role in Disease PathogenesisSemantic proximity Read ↗

Epstein-Barr virus reprograms human B-lymphocytes immediately in the pre-latent phase of infectionSemantic proximity Read ↗

Epstein–Barr Virus B Cell Growth Transformation: The Nuclear EventsSemantic proximity Read ↗

Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk lociSemantic proximity Read ↗

Identification of <i>MEF2B</i> , <i>EBF1</i> , and <i>IL6R</i> as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte SurvivalSemantic proximity Read ↗

Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic SitesSemantic proximity Read ↗

The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfoldSemantic proximity Read ↗

Characterization of Target Gene Regulation by the Two Epstein-Barr Virus Oncogene LMP1 Domains Essential for B-cell TransformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.