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Article

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

Developmental cell - 1 Mar 2008

Wu Shian, Liu Yi, Zheng Yonggang, Dong Jixin, Pan Duojia

Abstract excerpt

The Hippo (Hpo) kinase cascade restricts tissue growth by inactivating the transcriptional coactivator Yorkie (Yki), which regulates the expression of target genes such as the cell death inhibitor diap1 by unknown mechanisms. Here we identify the TEAD/TEF family protein Scalloped (Sd) as a DNA-binding transcription factor that partners with Yki to mediate the transcriptional output of the Hpo growth-regulatory...

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Source

Identifiers

PMID: 18258486
DOI: 10.1016/j.devcel.2008.01.007

Genes

TEF

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Related research

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The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.PMID 18258486Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.Semantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ SizeSemantic proximity Read ↗

Pits and CtBP control tissue growth in <i>Drosophila melanogaster</i> with the Hippo pathway transcription repressor, TgiSemantic proximity Read ↗

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.Semantic proximity Read ↗

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression.Semantic proximity Read ↗

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