Article
Genetic relatedness of Plasmodium falciparum isolates and the origin of allelic diversity at the merozoite surface protein-1 (MSP-1) locus in Brazil and Vietnam.
Malaria journal - 23 Jul 2003
Hoffmann Erika H E, Ribolla Paulo E M, Ferreira Marcelo U
Abstract excerpt
BACKGROUND: Despite the extensive polymorphism at the merozoite surface protein-1 (MSP-1) locus of Plasmodium falciparum, that encodes a major repetitive malaria vaccine candidate antigen, identical and nearly identical alleles frequently occur in sympatric parasites. Here we used microsatellite haplotyping to estimate the genetic distance between isolates carrying identical and nearly identical MSP-1 alleles....
Topics
- Alleles
- Animals
- Brazil
- Founder Effect
- Genetic Markers
- Genetic Variation
- Haplotypes
- Humans
- Malaria, Falciparum
- Merozoite Surface Protein 1
- Microsatellite Repeats