Article
Allelic diversity at the merozoite surface protein-1 (MSP-1) locus in natural Plasmodium falciparum populations: a brief overview.
Memorias do Instituto Oswaldo Cruz - 1 Jan 2000
Ferreira M U, Kaneko O, Kimura M, Liu Q, Kawamoto F, Tanabe K
Abstract excerpt
The merozoite surface protein-1 (MSP-1) locus of Plasmodium falciparum codes for a major asexual blood-stage antigen currently proposed as a major malaria vaccine candidate. The protein, however, shows extensive polymorphism, which may compromise its use in sub-unit vaccines. Here we compare the patterns of allelic diversity at the MSP-1 locus in wild isolates from three epidemiologically distinct malaria-endemic...
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