Article
Geographical patterns of allelic diversity in the Plasmodium falciparum malaria-vaccine candidate, merozoite surface protein-2.
Annals of tropical medicine and parasitology - 1 Mar 2001
Hoffmann E H, da Silveira L A, Tonhosolo R, Pereira F J, Ribeiro W L, Tonon A P, Kawamoto F, Ferreira M U
Abstract excerpt
The polymorphic merozoite surface protein-2 (MSP-2) of Plasmodium falciparum is a major malaria-vaccine candidate. In the present study, PCR and hybridization with allelic-specific probes were used to type the Msp-2 gene from isolates from hypo-endemic Brazil (N = 113), meso-endemic Vietnam (N = 208) and holo-endemic Tanzania (N = 67). The typing methods were designed to group isolates into the dimorphic allelic...
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