Article
Allelic diversity in the merozoite surface protein-1 and epidemiology of multiple-clone Plasmodium falciparum infections in northern Tanzania.
The Journal of parasitology - 1 Dec 1998
Ferreira M U, Liu Q, Kimura M, Ndawi B T, Tanabe K, Kawamoto F
Abstract excerpt
Allelic diversity in the merozoite surface protein-1 (MSP-1) of Plasmodium falciparum, a major malaria vaccine candidate, was examined in clinical isolates from holoendemic northern Tanzania. The variable blocks 2, 4a, 4b, 6, and 10 of the MSP-1 gene were typed by allelic type-specific polymerase chain reaction. Twenty-four possible MSP-1 gene types were defined as unique combinations of allelic types detected in...
Topics
- Adolescent
- Adult
- Alleles
- Animals
- Antigens, Protozoan
- Antigens, Surface
- Child
- Child, Preschool
- Female
- Genetic Variation
- Humans
- Infant