Article
Sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-1 (MSP-1) of Plasmodium falciparum.
Gene - 30 Jan 2003
Ferreira Marcelo U, Ribeiro Weber L, Tonon Angela P, Kawamoto Fumihiko, Rich Stephen M
Abstract excerpt
The merozoite surface protein-1 (MSP-1) of the malaria parasite Plasmodium falciparum is a major blood-stage antigen containing highly polymorphic tripeptide repeats in the domain known as block 2 and several non-repetitive domains that are essentially dimorphic. We have analyzed sequence variation in block 2 repeats and in non-repetitive block 17, as well as other polymorphisms within the MSP-1 gene, in clinical...
Topics
- Alleles
- Animals
- Brazil
- DNA, Protozoan
- Evolution, Molecular
- Genetic Variation
- Haplotypes
- Linkage Disequilibrium
- Malaria Vaccines
- Merozoite Surface Protein 1
- Molecular Sequence Data