Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Nonsense Mutation in the <i>ERG6</i> Gene Leads to Reduced Susceptibility to Polyenes in a Clinical Isolate of <i>Candida glabrata</i>

12 Aug 2008

Abstract excerpt

Unlike the molecular mechanisms that lead to azole drug resistance, the molecular mechanisms that lead to polyene resistance are poorly documented, especially in pathogenic yeasts. We investigated the molecular mechanisms responsible for the reduced susceptibility to polyenes of a clinical isolate of Candida glabrata. Sterol content was analyzed by gas-phase chromatography, and we determined the sequences and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal and yeast genetics research
Share to Fungal Biology and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18694952
DOI: 10.1128/aac.00423-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Nonsense Mutation in the <i>ERG6</i> Gene Leads to Reduced Susceptibility to Polyenes in a Clinical Isolate of <i>Candida glabrata</i>PMID 18694952Read ↗

Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth.Semantic proximity Read ↗

Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complexSemantic proximity Read ↗

Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.Semantic proximity Read ↗

Azole-Resistant Alleles of ERG11 in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors.Semantic proximity Read ↗

Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrataSemantic proximity Read ↗

Rare modification in the ergosterol biosynthesis pathway leads to amphotericin B resistance in <i>Candida auris</i> clinical isolatesSemantic proximity Read ↗

Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

Redefining Pleiotropic Drug Resistance in a Pathogenic Yeast: Pdr1 Functions as a Sensor of Cellular Stresses in <i>Candida glabrata</i>Semantic proximity Read ↗

<i>In vivo</i> emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in <i>Candida auris</i>Semantic proximity Read ↗

Acquired Amphotericin B Resistance Attributed to a Mutated <i>ERG3</i> in <i>Candidozyma auris</i>Semantic proximity Read ↗

Loss-of-function <i>ROX1</i> mutations suppress the fluconazole susceptibility of <i>upc2A</i> Δ mutation in <i>Candida glabrata</i> , implicating additional positive regulators of ergosterol biosynthesisSemantic proximity Read ↗

Upregulation of the Adhesin Gene <i>EPA1</i> Mediated by <i>PDR1</i> in Candida glabrata Leads to Enhanced Host ColonizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.