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Article

Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans.

Fungal genetics and biology : FG & B - 1 Jul 2020

Oliveira Fabiana Freire M, Paes Hugo Costa, Peconick Luísa Defranco F, Fonseca Fernanda L, Marina Clara Luna Freitas, Bocca Anamélia Lorenzetti, Homem-de-Mello Mauricio, Rodrigues Márcio Lourenço, Albuquerque Patrícia, Nicola André Moraes, Alspaugh J Andrew, Felipe Maria Sueli S, Fernandes Larissa

Abstract excerpt

Ergosterol is the most important membrane sterol in fungal cells and a component not found in the membranes of human cells. We identified the ERG6 gene in the AIDS-associated fungal pathogen, Cryptococcus neoformans, encoding the sterol C-24 methyltransferase of fungal ergosterol biosynthesis. In this work, we have explored its relationship with high-temperature growth and virulence of C. neoformans by the...

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Identifiers

PMID: 32201128
DOI: 10.1016/j.fgb.2020.103368
PMCID: PMC7293587

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