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Article

Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities.

The Journal of antibiotics - 1 Aug 2010

Campoy Sonia, Sierra Saleta, Suarez Beatriz, Ramos Maria C, Velasco Javier, Burgos Javier S, Adrio Jose L

Abstract excerpt

A fungal strain able to naturally accumulate large amounts of monacolin J was improved by N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis and genetic disruption of the lovF gene. Semisynthesis was then used to produce novel statins by attaching different side chains at the C8 hydroxyl residue. I...

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Identifiers

PMID: 20648024
DOI: 10.1038/ja.2010.76

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20648024-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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