Biosynthesis of ganefromycin: results from blocked mutants and bioconversion experiments.

doi:10.1021/np970408i

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Article

Biosynthesis of ganefromycin: results from blocked mutants and bioconversion experiments.

Journal of natural products - 1 Feb 1998

McDonald L A, Lotvin J A, Bailey A E, Carter G T

Abstract excerpt

The biosynthetic pathway of ganefromycin alpha (8) was investigated using blocked mutants of Streptomyces lydicus spp. tanzanius, the ganefromycin alpha producer, in conjunction with bioconversion experiments with the products of these mutants. Compounds 1-7 and 9-15, which are structurally relat...

Topics

Anti-Bacterial Agents
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Furans
Magnetic Resonance Spectroscopy
Mutagenesis, Site-Directed
Mutation
Spectrophotometry, Ultraviolet
Streptomyces

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