Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring mutasynthesis to increase structural diversity in the synthesis of highly oxygenated polyketide lactones.

Organic & biomolecular chemistry - 28 Jul 2014

Botubol-Ares J M, Durán-Peña M J, Macías-Sánchez A J, Hanson J R, Collado I G, Hernández-Galán R

Abstract excerpt

The enantioselective synthesis of (2R,3R,4E,8E)-3-hydroxy-2,4,8-trimethyldeca-4,8-dienolide (5) by ring-closing metathesis is described. This compound is an analogue of 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (4) which is a rare 11-membered lactone produced by the fungus, Botrytis cinerea. Mutasynthetic studies with compound 5 using two mutants of B. cinerea led to the isolation of four new highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Botrytis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epoxy Compounds

Share to Hydroxylation

Share to Lactones

Share to Molecular Structure

Share to Oxygen

Share to Stereoisomerism

Source

Identifiers

PMID: 24927251
DOI: 10.1039/c4ob00717d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring mutasynthesis to increase structural diversity in the synthesis of highly oxygenated polyketide lactones.PMID 24927251Read ↗

Enantioselective Synthesis of Bicyclic Lactone Enabled by Tunnel Reshaping of Polycyclic Ketone Monooxygenase.Semantic proximity Read ↗

Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products.Semantic proximity Read ↗

Mutasynthesis - uniting chemistry and genetics for drug discovery.Semantic proximity Read ↗

Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics.Semantic proximity Read ↗

First Ring-Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant.Semantic proximity Read ↗

Directed evolution as a method to create enantioselective cyclohexanone monooxygenases for catalysis in Baeyer-Villiger reactions.Semantic proximity Read ↗

Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering.Semantic proximity Read ↗

Towards practical Baeyer-Villiger-monooxygenases: design of cyclohexanone monooxygenase mutants with enhanced oxidative stability.Semantic proximity Read ↗

Directed evolution of cyclohexanone monooxygenases: enantioselective biocatalysts for the oxidation of prochiral thioethers.Semantic proximity Read ↗

Laboratory evolution of robust and enantioselective Baeyer-Villiger monooxygenases for asymmetric catalysis.Semantic proximity Read ↗

Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade.Semantic proximity Read ↗

A diversity oriented synthesis of natural product inspired molecular libraries.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.