Article
Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2012
Ames Brian D, Nguyen Chi, Bruegger Joel, Smith Peter, Xu Wei, Ma Suzanne, Wong Emily, Wong Steven, Xie Xinkai, Li Jesse W-H, Vederas John C, Tang Yi, Tsai Shiou-Chuan
Abstract excerpt
Lovastatin is an important statin prescribed for the treatment and prevention of cardiovascular diseases. Biosynthesis of lovastatin uses an iterative type I polyketide synthase (PKS). LovC is a trans-acting enoyl reductase (ER) that specifically reduces three out of eight possible polyketide intermediates during lovastatin biosynthesis. Such trans-acting ERs have been reported across a variety of other fungal...
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