Article
Pentaketide melanin biosynthesis in Aspergillus fumigatus requires chain-length shortening of a heptaketide precursor.
The Journal of biological chemistry - 3 Aug 2001
Tsai H F, Fujii I, Watanabe A, Wheeler M H, Chang Y C, Yasuoka Y, Ebizuka Y, Kwon-Chung K J
Abstract excerpt
Chain lengths and cyclization patterns of microbial polyketides are generally determined by polyketide synthases alone. Fungal polyketide melanins are often derived from a pentaketide 1,8-dihydroxynaphthalene, and pentaketide synthases are used for synthesis of the upstream pentaketide precursor, 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN). However, Aspergillus fumigatus, a human fungal pathogen, uses a...
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