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Article

First Ring-Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant.

Chembiochem : a European journal of chemical biology - 15 Oct 2020

Wesemann Friederike, Heutling Anja, Wienecke Paul, Kirschning Andreas

Abstract excerpt

A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early building block as well as in the expression of two tailoring enzymes broadens the scope of chemo-biosynthetic access...

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PMID: 32484951
DOI: 10.1002/cbic.202000336
PMCID: PMC7689855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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