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Article

Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.

Chemistry & biology - 1 Nov 2006

Xie Xinkai, Watanabe Kenji, Wojcicki Wladyslaw A, Wang Clay C C, Tang Yi

Abstract excerpt

The natural product lovastatin and its semisynthetic, more effective derivative, simvastatin, are important drugs for the treatment of hypercholesterolemia. Here, we report the biochemical characterization of a dedicated acyltransferase, LovD, encoded in the lovastatin biosynthetic pathway. We demonstrate that LovD has broad substrate specificity towards the acyl carrier, the acyl substrate, and the decalin acyl...

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Source

Identifiers

PMID: 17113998
DOI: 10.1016/j.chembiol.2006.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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