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Article

Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease.

Neurobiology of aging - 1 Nov 2003

Baxter Leslie C, Caselli Richard J, Johnson Sterling C, Reiman Eric, Osborne David

Abstract excerpt

The Apolipoprotein E (APOE) epsilon 4 allele is an important risk factor for Alzheimer's disease (AD). Given the interest in early identification of at-risk individuals, we examined memory decline as a function of APOE status and age in cognitively intact participants aged 48-77 years old (yo). Participants were grouped by age (<60 versus > or =60) and APOE (epsilon4+/-). Longitudinal analysis of several...

Topics

Aged
Aging
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Longitudinal Studies
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Memory

Middle Aged

Risk Factors

Verbal Learning

Source

Identifiers

PMID: 12928055
DOI: 10.1016/s0197-4580(03)00006-x

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12928055-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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