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Article

Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1.

Molecular cell - 8 Oct 2004

Bianchi Alessandro, Negrini Simona, Shore David

Abstract excerpt

The yeast single-strand TG-repeat telomere binding protein Cdc13 and the telomerase accessory protein Est1 play essential roles in chromosome end replication. To determine whether a proposed Cdc13-Est1 interaction recruits telomerase (Est2), we used a simplified system in which telomere formation was monitored at an HO-induced DNA double-strand break (DSB). Tethering of either Cdc13 or Est1 adjacent to a DSB...

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Identifiers

PMID: 15469829
DOI: 10.1016/j.molcel.2004.09.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1.PMID 15469829Read ↗

Est1 and Cdc13 as comediators of telomerase access.Semantic proximity Read ↗

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Semantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

Est1p as a cell cycle-regulated activator of telomere-bound telomerase.Semantic proximity Read ↗

Est1 protects telomeres and inhibits subtelomeric y'-element recombination.Semantic proximity Read ↗

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment.Semantic proximity Read ↗

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.Semantic proximity Read ↗

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.Semantic proximity Read ↗

Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

A second essential function of the Est1-binding arm of yeast telomerase RNA.Semantic proximity Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

A quantitative assay for telomere protection in Saccharomyces cerevisiae.Semantic proximity Read ↗

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