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Article

Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008

Haan Serge, Margue Christiane, Engrand Arnaud, Rolvering Catherine, Schmitz-Van de Leur Hildegard, Heinrich Peter C, Behrmann Iris, Haan Claude

Abstract excerpt

Jak1 is a tyrosine kinase that noncovalently forms tight complexes with a variety of cytokine receptors and is critically involved in signal transduction via cytokines. Jaks are predicted to have a 4.1, ezrin, radixin, moesin (FERM) domain at their N terminus. FERM domains are composed of three s...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18178840
DOI: 10.4049/jimmunol.180.2.998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18178840-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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