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Article

The GH receptor and GH insensitivity.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Jun 1999

Ross R J

Abstract excerpt

Growth hormone (GH) resistance/insensitivity (GHIS) is the finding of elevated GH levels associated with a reduction in the biologic actions of GH. It may be congenital or acquired. In congenital GHIS, over 30 mutations in the GH receptor (GHR) have been described. Dimerization of the GHR activates phosphorylation cascades involving MAP kinases and the Janus kinase, JAK2. This in turn activates the STAT (Signal...

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Source

Identifiers

PMID: 10549305
DOI: 10.1016/s1096-6374(99)80080-x

Genes

GHR
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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