Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation of genotype, phenotype, and mRNA expression of CYP2D6 and CYP2C19 in peripheral blood leukocytes (PBLs).

International journal of clinical pharmacology and therapeutics - 1 Feb 2014

Kuhlmann Jan B, Wensing Georg, Kuhlmann Jochen

Abstract excerpt

INTRODUCTION: The genetic polymorphism of drug metabolizing enzymes of the cytochrome P450 (CYP) families, especially CYP2D6 and CYP2C19, is the most important cause of variable responses of many drugs. Enzyme activity ranges from complete deficiency, so called poor metabolizers (PMs), to an ultrafast metabolism. While PMs and extensive metabolizers (EMs) can be well distinguished by genotyping, phenotyping is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA, Messenger
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Cytochrome P-450 CYP2D6

Share to Dextromethorphan

Share to Leukocytes

Share to Omeprazole

Share to Young Adult

Source

Identifiers

PMID: 24361088
DOI: 10.5414/CP201966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correlation of genotype, phenotype, and mRNA expression of CYP2D6 and CYP2C19 in peripheral blood leukocytes (PBLs).PMID 24361088Read ↗

Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships.Semantic proximity Read ↗

The prevalence of CYP2D6 and CYP2C19 genotypes in a population of healthy Dutch volunteers.Semantic proximity Read ↗

An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19.Semantic proximity Read ↗

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes.Semantic proximity Read ↗

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.Semantic proximity Read ↗

Estimation of drug-metabolizing capacity by cytochrome P450 genotyping and expression.Semantic proximity Read ↗

Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes.Semantic proximity Read ↗

Cytochrome P450 2D6 polymorphism in eastern Indian population.Semantic proximity Read ↗

Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice.Semantic proximity Read ↗

CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences.Semantic proximity Read ↗

Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects.Semantic proximity Read ↗

Evaluation of cytochrome P450 2D6 phenotyping in healthy adult Western Indians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.