Article
Plasmid-mediated complementation of gyrA and gyrB in fluoroquinolone-resistant Bacteroides fragilis.
The Journal of antimicrobial chemotherapy - 1 Sept 2003
Peterson M L, Rotschafer J C, Piddock L J V
Abstract excerpt
OBJECTIVES: To identify whether mutations in gyrA and gyrB confer fluoroquinolone resistance in Bacteroides fragilis. METHODS: Eight fluoroquinolone-resistant (FQR) strains were complemented with plasmid-mediated B. fragilis wild-type gyrA (pMP1) and gyrB (pMP2), and MICs determined. Sequence analysis of the gyrA and gyrB quinolone resistance determining region (QRDR) was performed for all strains. RESULTS: MICs...
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