Plasmid-mediated complementation of gyrA and gyrB in fluoroquinolone-resistant Bacteroides fragilis.

doi:10.1093/jac/dkg368

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Article

Plasmid-mediated complementation of gyrA and gyrB in fluoroquinolone-resistant Bacteroides fragilis.

The Journal of antimicrobial chemotherapy - 1 Sept 2003

Peterson M L, Rotschafer J C, Piddock L J V

Abstract excerpt

OBJECTIVES: To identify whether mutations in gyrA and gyrB confer fluoroquinolone resistance in Bacteroides fragilis. METHODS: Eight fluoroquinolone-resistant (FQR) strains were complemented with plasmid-mediated B. fragilis wild-type gyrA (pMP1) and gyrB (pMP2), and MICs determined. Sequence analysis of the gyrA and gyrB quinolone resistance determining region (QRDR) was performed for all strains. RESULTS: MICs...

Topics

Anti-Bacterial Agents
Bacteroides fragilis
DNA Gyrase
Drug Resistance, Bacterial
Fluoroquinolones
Genetic Complementation Test
Microbial Sensitivity Tests
Mutation
Phenotype
Plasmids
Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 12917248
DOI: 10.1093/jac/dkg368

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