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Article

Molecular cloning of the gyrA and gyrB genes of Bacteroides fragilis encoding DNA gyrase.

Antimicrobial agents and chemotherapy - 1 Oct 1999

Onodera Y, Sato K

Abstract excerpt

The genes encoding the DNA gyrase A and B subunits of Bacteroides fragilis were cloned and sequenced. The gyrA and gyrB genes code for proteins of 845 and 653 amino acids, respectively. These proteins were expressed in Escherichia coli, and the combination of GyrA and GyrB exhibited ATP-dependent supercoiling activity. To analyze the role of DNA gyrase in quinolone resistance of B. fragilis, we isolated mutant...

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Identifiers

PMID: 10508019
DOI: 10.1128/AAC.43.10.2423
PMCID: PMC89495

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