Article
Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis.
The Journal of antimicrobial chemotherapy - 1 Oct 2014
Veeranagouda Yaligara, Husain Fasahath, Boente Renata, Moore Jane, Smith C Jeffrey, Rocha Edson R, Patrick Sheila, Wexler Hannah M
Abstract excerpt
BACKGROUND: Metronidazole is the most commonly used antimicrobial for Bacteroides fragilis infections and is recommended for prophylaxis of colorectal surgery. Metronidazole resistance is increasing and the mechanisms of resistance are not clear. METHODS: A transposon mutant library was generated in B. fragilis 638R (BF638R) to identify the genetic loci associated with resistance to metronidazole. RESULTS:...
Topics
- Anti-Bacterial Agents
- Bacteroides fragilis
- Cation Transport Proteins
- DNA Transposable Elements
- Drug Resistance, Bacterial
- Ferrous Compounds
- Gene Deletion
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Gene Library
- Gene Order