Article
A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium.
FEMS microbiology letters - 1 Oct 1995
Gensberg K, Jin Y F, Piddock L J
Abstract excerpt
In order to study the role of gyrB in antibiotic resistance in post-ciprofloxacin therapy fluoroquinolone-resistant clinical isolates of Salmonella typhimurium, plasmid pBP548, which contains the Escherichia coli gyrB gene, was used in complementation studies. In a heterodiploid strain, the wild-type (quinolone sensitive) allele is dominant over the resistant allele therefore, eleven clinical isolates were...
Topics
- Anti-Infective Agents
- Base Sequence
- Ciprofloxacin
- DNA Gyrase
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data