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Article

DNA gyrase and topoisomerase IV mutations associated with fluoroquinolone resistance in Proteus mirabilis.

Antimicrobial agents and chemotherapy - 1 Aug 2002

Weigel L M, Anderson G J, Tenover F C

Abstract excerpt

Mutations associated with fluoroquinolone resistance in clinical isolates of Proteus mirabilis were determined by genetic analysis of the quinolone resistance-determining region (QRDR) of gyrA, gyrB, parC, and parE. This study included the P. mirabilis type strain ATCC 29906 and 29 clinical isola...

Topics

Amino Acid Sequence
Amino Acid Substitution
Anti-Infective Agents
DNA Gyrase
DNA Primers
DNA Topoisomerase IV
DNA, Bacterial
Drug Resistance, Microbial
Fluoroquinolones
Microbial Sensitivity Tests
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Proteus mirabilis

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 12121936
DOI: 10.1128/AAC.46.8.2582-2587.2002
PMCID: PMC127365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-12121936-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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