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DNA gyrase and topoisomerase IV mutations associated with fluoroquinolone resistance in Proteus mirabilis.

Antimicrobial agents and chemotherapy - 1 Aug 2002

Weigel L M, Anderson G J, Tenover F C

Abstract excerpt

Mutations associated with fluoroquinolone resistance in clinical isolates of Proteus mirabilis were determined by genetic analysis of the quinolone resistance-determining region (QRDR) of gyrA, gyrB, parC, and parE. This study included the P. mirabilis type strain ATCC 29906 and 29 clinical isolates with reduced susceptibility (MIC, 0.5 to 2 microg/ml) or resistance (MIC, > or =4 microg/ml) to ciprofloxacin....

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Identifiers

PMID: 12121936
DOI: 10.1128/AAC.46.8.2582-2587.2002
PMCID: PMC127365

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Source receipt: pubmed, retrieved 7 Sept 2026.

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