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Article

Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole.

Research in microbiology - 1 Jun 2010

Steffens Laura S, Nicholson Samantha, Paul Lynthia V, Nord Carl Erik, Patrick Sheila, Abratt Valerie R

Abstract excerpt

Bacteroides fragilis is a human gut commensal and an opportunistic pathogen causing anaerobic abscesses and bacteraemias which are treated with metronidazole (Mtz), a DNA damaging agent. This study examined the role of the DNA repair protein, RecA, in maintaining endogenous DNA stability and its contribution to resistance to Mtz and other DNA damaging agents. RT-PCR of B. fragilis genomic DNA showed that the recA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20435137
DOI: 10.1016/j.resmic.2010.04.003
PMCID: PMC3025348

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Source receipt: pubmed, retrieved 7 Sept 2026.

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