Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem.

doi:10.1128/AAC.39.10.2248

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Article

Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem.

Antimicrobial agents and chemotherapy - 1 Oct 1995

Cambau E, Perani E, Dib C, Petinon C, Trias J, Jarlier V

Abstract excerpt

In Pseudomonas aeruginosa, resistance to imipenem is mainly related to a lack of protein OprD and resistance to fluoroquinolones is mainly related to alterations in DNA gyrase. However, strains cross resistant to fluoroquinolones and imipenem have been selected in vitro and in vivo with fluoroqui...

Topics

Anti-Infective Agents
Ciprofloxacin
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Imipenem
Microbial Sensitivity Tests
Mutation
Pseudomonas aeruginosa
Thienamycins

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