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Article

Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression.

Science (New York, N.Y.) - 14 Dec 2007

Egloff Sylvain, O'Reilly Dawn, Chapman Rob D, Taylor Alice, Tanzhaus Katrin, Pitts Laura, Eick Dirk, Murphy Shona

Abstract excerpt

RNA polymerase II (Pol II) transcribes genes that encode proteins and noncoding small nuclear RNAs (snRNAs). The carboxyl-terminal repeat domain (CTD) of the largest subunit of mammalian RNA Pol II, comprising tandem repeats of the heptapeptide consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7, is req...

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Identifiers

PMID: 18079403
DOI: 10.1126/science.1145989
PMCID: PMC2263945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18079403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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