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Article

Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

Genetics - 1 Aug 1995

West M L, Corden J L

Abstract excerpt

The carboxyl-terminal domain (CTD) of the RNA polymerase II largest subunit plays an essential but poorly understood role in transcription. The CTD is highly phosphorylated in vivo and this modification may be important in the transition from transcription initiation to elongation. We report here the development of a strategy for creating novel yeast CTDs. We have used this approach to show that the minimum...

Topics

Amino Acid Sequence
Base Sequence
Consensus Sequence
Fungal Proteins
Molecular Sequence Data
Mutagenesis
Phenotype
Phosphorylation
Protein Kinases
RNA Polymerase II
Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Sequence Deletion

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7498765
DOI: 10.1093/genetics/140.4.1223
PMCID: PMC1206689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7498765-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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