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Article

An orc1 allele with a mutated APC motif is female sterile with amplification defects.

Cell cycle (Georgetown, Tex.) - 1 Aug 2012

Park So Young, Asano Maki

Abstract excerpt

The origin recognition complex 1 (ORC1) is the largest subunit of the ORC, the heteromeric hexamer. ORC1 is an essential component of the pre-replicative complex (pre-RC) that licenses eukaryote DNA replication origins. The levels of ORC1 fluctuate during the mitotic cell cycle in Drosophila as well as in some human cells. Proteolysis of ORC1 occurs at the end of M phase in Drosophila, which is mediated by the...

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Source

Identifiers

PMID: 22801552
DOI: 10.4161/cc.21168

Genes

ORC1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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